GENETIKA, Vol

GENETIKA, Vol. 11, No.3 (1979)

Emira ĐURIČIĆ, Nada SAVKOVIĆ and T. KILALIĆ

CHROMOSOMAL ABERRATIONS INDUCED DURING MITOSIS IN MICE [Abstract]

N. TUCIĆ and D. MARINKOVIĆ

THE INHERITANCE OF LIABILITY TO BALKAN NEPHROPATHY [Abstract]

D. BANJEVIĆ and N. TUCIĆ

THE MONOFACTORIAL MODEL FOR INHERITANCE OF LIABILITY TO DISEASE AND ITS IMPLICATIONS FOR RELATIVES AT RISK [Abstract]

Danica KORAĆ

GENETIC COUNSELLING [Abstract]

Milena ĆIRIĆ

EVOLUTION OF THE KARYOTYPE IN NEOPLASIA [Abstract]

Z. ROLOVIĆ

CYTOGENETICS IN HEMATOLOGICAL MALIGNANCIES. CURRENT STATUS AND FURTHER ROLE [Abstract]

Živana LAĆA and Vesna DRAMUŠIĆ

BROMODEOXIURIDINE IN CYTOGENETIC INVESTIGATIONS AN INVESTIGATION OF SISTER CHROMATID EXCHANGE (SCE) AND CELL KINETICS IN A GROUP OF FEMALE PATIENTS WITH GONADAL DYSGENESIS [Abstract]

Slavka MORIĆ-PETROVIĆ

CURRENT TRENDS AND THE DEVELOPMENT OF HUMAN GENETICS IN YUGOSLAVIA [Abstract]

Marija GUĆ and B. GARZIČIĆ

MECHANISMS OF INACTIVATION OF X CHROMOSOME IN THE MAMMALIAN FEMALE CHROMOSOME COMPLEMENT [Abstract]

Branka KRAJINČANIĆ and B. SOLDATOVIĆ

ANALYSIS OF KARIOTYPE IN A GROUP OF CHILDREN WITH PHYSICAL STIGMATA [Abstract]

Sofija POPOVIĆ and A. POPOVIĆ

THE EFFECT OF BACKCROSSING ON IMPROVEMENT OF WHEAT QUALITY [Abstract]

M. IVANOVIĆ, Marija KRALJEVIĆ-BALALIĆ and K. ROSIĆ

COMBINING ABILITY FOR GRAIN YIELD AND STALK ROT INDEX IN MAIZE [Abstract]

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 203-212

Serbia

Original scientific paper

CHROMOSOMAL ABERRATIONS INDUCED DURING MITOSIS IN MICE

Emira ĐURIČIĆ, Nada SAVKOVIĆ¹ and T. KILALIĆ

Institut za medicinsku biologiju, Medicinski fakultet, 71000 Sarajevo, Jugoslavija¹

Laboratorija za radiobiologiju, Institut »Boris Kidrič«, Vinča, p. fah 522, 11001 Beograd, Jugoslavija

Abstract

Đuričić, E., Savković, N. and Kilalić, T. (1979): Chromosomal aberrations induced during mitosis in mice. - Genetika, Vol. 11, No. 3, 203-212.

The present study is an analysis of atypical chromosomes produced in male mice by treatment with 5 mg/kg busulphan (Myleran), or 150 mg/kg or 350 mg/kg cyclophosphamide (Endoxan). The rate of inductions of chromosome aberrations in metaphase was determined by cytological examination of meta-phase at different times 24 hours and 6 days after treatment. The cytogenetic effects of Myleran and Endoxan were examined in bone marrow cells from male mice. In the present study, therefore, we investigated the types of chromosomal aberrations as well as the dose - and time - response relationships in bone - marrow cells of male mice treated with Myleran and Endoxan.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 213-219

Serbia

Original scientific paper

THE INHERITANCE OF LIABILITY TO BALKAN NEPHROPATHY

N. TUCIĆ and D. MARINKOVIĆ

Faculty of Science and Institute of Biological Research 11000 Beograd, Yugoslavia

Abstract

Tucić, N. and Marinković, D. (1979): The inheritance of liability to Balkan nephropathy. - Genetika, Vol. 11, No. 3, 213-219.

In this paper, correlations which estimate the liability to develop Balkan nephropathy are made in the population from a region in Yugoslavia where Balkan nephropathy is common, in order to measure the degree to which the disease is genetically controlled. This is done by comparing the population prevalence of the disease with the prevalence among first-degree relatives of affected individuals. In the analysis presented here the Multi-factorial Model proposed by Falconer (1965) is used. In this Model the genetic component is considered to be polygenic. An alternative mechanism of inheritance which involves a single gene with incomplete penetrance has also been discussed.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 221-230

Serbia

Original scientific paper

THE MONOFACTORIAL MODEL FOR INHERITANCE OF LIABILITY TO DISEASE AND ITS IMPLICATIONS FOR RELATIVES AT RISK

D. BANJEVIĆ and N. TUCIĆ

Faculty of Science and Institute of Biological Research 11000 Beograd, Yugoslavia

Abstract

Banjević, D. and Tucić, N. (1979): The monofactorial model for inheritance of liability to disease and its implications ior relatives at risk. - Genetika, Vol. 11, No. 3, 221-230.

In this paper an attempt is made to develop a model which estimates the liability to a condition determined by a part of the genotype which is transmitted as a unit (»single Mendelian gene«), but which is expressed only in homozygotes (»recessive« gene) in a certain range of environments. This model implies that the transmission of common familial diseases could be explained on the basis of a single recessive gene with failure of penetrance in homozygous combinations. The Monofactorial model of disease transmission appears to be a powerful device for the analysis of population and family data. The model of mono-factorial liability can be useful in genetic counselling in helping to predict the possible frequency of disease and the chance of recurrence in relatives.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 231-237

Serbia

Original scientific paper

GENETIC COUNSELLING

Danica KORAĆ

Dečja klinika Medicinskog fakulteta, 11000 Beograd, Jugoslavija

Abstract

Korać, D. (1979): Genetic counselling. - Genetika, Vol. 11, No. 3, 231-237.

The genetic counsellor determines the risk to further offspring most often in families who already have a child with congenital malformations. In the 330 families studied it was found that genetic counselling was of the highest value and use in regard to malformations which can be treated after 'birth or detected prenatally early enough for the pregnancy to be interrupted. In cases where anomalies were transmitted by the simple Men-deliar law and which can be neither treated nor revealed prenatally, it was not possible to help parents to make the decision whether to risk conceiving another child or not. In some malformations, particularly those of heterogenous etiology, it was not possible even roughly, to determine the recurrence risk to further offspring.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 239-255

Serbia

Original scientific paper

EVOLUTION OF THE KARYOTYPE IN NEOPLASIA

Milena ĆIRIĆ

Medicinski fakultet, 11000 Beograd, Jugoslavija

Abstract

Ćirić, M. (1979): Evolution of the karyotype in neoplasia. - Genetika, Vol. 11, No. 3, 239-255.

Considering ithe general principles of karyotypic evolution in neoplastic cell populations, the author has reported some investigations of the process in chronic myeloid leukemia (CML) and on experimental tumour. On the basis of these results and those in the extensively studied literature, the author considerse that the divergent character of the karyotypic evolution in CML is equal to the single direction.

By means of the T-G band technique the author determined precisely the moment and the mechanism of stemline formation. Besides its theoretical interest the problem also has practical implications, but very few data have been reported so far.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 257-265

Serbia

Original scientific paper

CYTOGENETICS IN HEMATOLOGICAL MALIGNANCIES. CURRENT STATUS AND FURTHER ROLE

Z. ROLOVIĆ

Interna klinika »B«, Medicinski fakultet, 11000 Beograd, Jugoslavija

Abstract

Roloviic, Z. (1979): Cytogenetics in hematological malignancies. Current status and further role. - Genetika, Vol. 11, No. 3, 257-265.

This is a review of the cytogenetical data relevant to the understanding and clarification of the basic problems in hematological malignancies. These problems have been classified as follows: (a) Definition of the premalignant state of hematopoietic tissue; (b) Initiation of neoplastic proliferation; (c) Mechanisms of clonal evolution of malignant cell populations; and (d) Clinical, hematological and biological expression of malignant cell populations.

The role of cytogenetical investigation in clarifying each problem was discussed and the need for a multidisciplinary approach in the future was emphasized.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 267-273

Serbia

Original scientific paper

BROMODEOXIURIDINE IN CYTOGENETIC INVESTIGATIONS AN INVESTIGATION OF SISTER CHROMATID EXCHANGE (SCE) AND CELL KINETICS IN A GROUP OF FEMALE PATIENTS WITH GONADAL DYSGENESIS

Živana LAĆA and Vesna DRAMUŠIĆ

Institut za mentalno zdravlje i Institut za zaštitu majke i deteta SR Srbije, 11000 Beograd, Jugoslavija

Abstract

Laća, Ž. and Dramušić, V. (1979): Bromodeoxiuridine in cytogenetic investigations. An investigation of sister chromatid exchange (SCE) and cell kinetics in a group of female patients with gonadal dysgenesis. - Genetika, Vol. 11, No. 3, 267-273.

This paper describes the possibilities offered by the use of 5-BrdU in the analysis of processes at a cytogenetic level. Data are presented on the analysis of sister chromatid exchange (SCE) frequency and on cell kinetics in a group of female patients with gonadal dysgenesis and aberant karyotypes.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 275-280

Serbia

Original scientific paper

CURRENT TRENDS AND THE DEVELOPMENT OF HUMAN GENETICS IN YUGOSLAVIA

Slavka MORIĆ-PETROVIĆ

Institut za mentalno zdravlje - Centar za medicinsku genetiku Beograd, Palmotićeva 37, Jugoslavija

Abstract

Moric-Petrović, S. (1979): Current trends and the development of human genetics in Yugoslavia. - Genetika, Vol. 11, No. 3, 275-280.

All the new advances in human genetics have also been reflected in our culture. After the association of knowledge in biology and medicine, a more rapid development of human genetics occurred. Thus, due to reduced morbidity from common infectious diseases, genetic diseases were much more noticeable. Genetic diseases have a social dimension because of the disability of the patient, the affliction borne by the family and the economic burden to the community.

Special significance in medical genetics is attributed to some prenatal measures which are based on: 1) precise diagnosis, 2) the identification of heterozygotes, 3) the possibilities of identifying a disorder using amniotic fluid. These procedures may be applied in monogenic disorders and for chromosomal aberrations, whereas the prevention of multifactorially caused diseases is considered to be more complex.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 281-289

Serbia

Original scientific paper

MECHANISMS OF INACTIVATION OF X CHROMOSOME IN THE MAMMALIAN FEMALE CHROMOSOME COMPLEMENT

Marija GUĆ and B. GARZIČIĆ

Institut za biološka istraživanja »S. Stanković« 11000 Beograd, Jugoslavija

Abstract

Guć, M. and Garzičić, B. (1979): Mechanisms of inactivation of X chromosome in the mammalian female chromosome complement. - Genetika, Vol. 11, No. 3, 281-289.

The mechanism by which one X chromosome in normal cells of female mammals becomes inactive, while the other, apparently identical chromosome remains active, is not known. Various recent hypotheses concerning these mechanisms are discussed.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 291-296

Serbia

Original scientific paper

ANALYSIS OF KARIOTYPE IN A GROUP OF CHILDREN WITH PHYSICAL STIGMATA

Branka KRAJINČANIĆ and B. SOLDATOVIĆ

Defektološki fakultet, Veterinarski fakultet Univerziteta u Beogradu 11000 Beograd, Jugoslavija

Abstract

Krajinčanić, B. and Soldatović, B. (1979): Analysis of kariotype in a group o/ children with physical stigmata. - Genetika, Vol. 11, No. 3, 291-296.

The aim of this research was to study whether there are any changes in the chromosome set in a group of children with physical stigmata.

There were 226 boys and 198 girls in the group of 424 children. A few degenerative signs were discovered in only 21 children for which reason kariostandardization of 'the children and their parents was performed where possible. In two children visible chromosomal structural aberrations were detected.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 297-306

Serbia

Original scientific paper

THE EFFECT OF BACKCROSSING ON IMPROVEMENT OF WHEAT QUALITY

Sofija POPOVIĆ and A. POPOVIĆ

Institut za strna žita, 34000 Kragujevac, Jugoslavija

Abstract

Popović, S. and Popović, A. (1979): The effect of backcrosslng on improvement of wheat quality. - Genetika, Vol. 11, No. 3, 297-306.

Different varieties have a different effect on the sedimentation value, which is one of the important parameters in breeding for quality. By one or two backcrossings it is possible to ascertain the effect of different parental varieties on the sedimentation value in progenies.

Hybrids which originate from crosses with Kragujevčanka 56 have a sedimentation value (SV) 83.6 ml, with Morava 58.3 ml, with Atlas 44.5 ml, and with the variety San Pastore 42.0 ml.

The sedimentation value has a very high heritability value in all combinations (from 0.53 - 0.86%). Heritability for plant height is 0.20 - 0.50%.

Return to content

Published in „GENETIKA“ Vol. 11, No.3 (1979), pp. 308-315

Serbia

Original scientific paper

COMBINING ABILITY FOR GRAIN YIELD AND STALK ROT INDEX IN MAIZE

M. IVANOVIĆ, Marija KRALJEVIĆ-BALALIĆ and K. ROSIĆ

Institut za kukuruz - Zemun Polje, 11080 Beograd Poljoprivredni fakultet, 21000 Novi Sad, Jugoslavija

Abstract

Ivanović, M., Kraljević-Balalić, M. and Rosić, K. (1979): Combining ability for grain yield and stalk rot index in maize. - Genetika, Vol. 11, No. 3, 308-315.

In diallel crossings of five maize inbred lines of different resistance to stalk rot and lodging, the stalk rot index and grain yield were investigated. Significant differences were found for both cases among investigated inbred lines.

In the F₁ generation the stalk rot index was inherited, depending on the combination, intermediary, partially or fully dominant, while the heterosis effect was also expressed for grain yield for all hybrids.

From the analysis of the general and specific combining ability, it can be concluded that for the stalk rot index the additive gene effect predominantes, while for grain yield the non-additive.

Return to content